Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development

Systematic genetic interaction profiles can reveal the mechanisms-of-action of bioactive compounds. The imipridone ONC201, which is currently in cancer clinical trials, has been ascribed a variety of different targets. To investigate the genetic dependencies of imipridone action, we screened a genom...

Descripción completa

Detalles Bibliográficos
Autores principales: Jacques, Samuel, van der Sloot, Almer M., C. Huard, Caroline, Coulombe-Huntington, Jasmin, Tsao, Sarah, Tollis, Sylvain, Bertomeu, Thierry, Culp, Elizabeth J., Pallant, Daniel, Cook, Michael A., Bonneil, Eric, Thibault, Pierre, Wright, Gerard D., Tyers, Mike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2020
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153937/
https://www.ncbi.nlm.nih.gov/pubmed/32094149
http://dx.doi.org/10.1534/genetics.119.302851

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153937/
https://www.ncbi.nlm.nih.gov/pubmed/32094149
http://dx.doi.org/10.1534/genetics.119.302851

Ejemplares similares