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Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development

Systematic genetic interaction profiles can reveal the mechanisms-of-action of bioactive compounds. The imipridone ONC201, which is currently in cancer clinical trials, has been ascribed a variety of different targets. To investigate the genetic dependencies of imipridone action, we screened a genom...

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Detalles Bibliográficos
Autores principales:	Jacques, Samuel, van der Sloot, Almer M., C. Huard, Caroline, Coulombe-Huntington, Jasmin, Tsao, Sarah, Tollis, Sylvain, Bertomeu, Thierry, Culp, Elizabeth J., Pallant, Daniel, Cook, Michael A., Bonneil, Eric, Thibault, Pierre, Wright, Gerard D., Tyers, Mike
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Genetics Society of America 2020
Materias:	Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153937/ https://www.ncbi.nlm.nih.gov/pubmed/32094149 http://dx.doi.org/10.1534/genetics.119.302851

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