Transduction optimization of AAV vectors for human gene therapy of glaucoma and their reversed cell entry characteristics

The trabecular meshwork (TM) of the eye is responsible for maintaining physiological intraocular pressure (IOP). Dysfunction of this tissue results in elevated IOP, subsequent optic nerve damage and glaucoma, the world’s leading cause of irreversible blindness. IOP regulation by delivering candidate...

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Detalles Bibliográficos
Autores principales: Rodriguez-Estevez, Laura, Asokan, Priyadarsini, Borrás, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153980/
https://www.ncbi.nlm.nih.gov/pubmed/31611639
http://dx.doi.org/10.1038/s41434-019-0105-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153980/
https://www.ncbi.nlm.nih.gov/pubmed/31611639
http://dx.doi.org/10.1038/s41434-019-0105-4

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