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Spadin Selectively Antagonizes Arachidonic Acid Activation of TREK-1 Channels
TREK-1 channel activity is a critical regulator of neuronal, cardiac, and smooth muscle physiology and pathology. The antidepressant peptide, spadin, has been proposed to be a TREK-1-specific blocker. Here we sought to examine the mechanism of action underlying spadin inhibition of TREK-1 channels....
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154116/ https://www.ncbi.nlm.nih.gov/pubmed/32317978 http://dx.doi.org/10.3389/fphar.2020.00434 |