PITX2 upregulation increases the risk of chronic atrial fibrillation in a dose-dependent manner by modulating I(Ks) and I(CaL)—insights from human atrial modelling

BACKGROUND: Functional analysis has shown that the paired-like homeodomain transcription factor 2 (PITX2) overexpression associated with atrial fibrillation (AF) leads to the slow delayed rectifier K(+) current (I(Ks)) increase and the L-type Ca(2+) current (I(CaL)) reduction observed in isolated ri...

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Detalles Bibliográficos
Autores principales: Bai, Jieyun, Lu, Yaosheng, Lo, Andy, Zhao, Jichao, Zhang, Henggui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154416/
https://www.ncbi.nlm.nih.gov/pubmed/32309338
http://dx.doi.org/10.21037/atm.2020.01.90

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154416/
https://www.ncbi.nlm.nih.gov/pubmed/32309338
http://dx.doi.org/10.21037/atm.2020.01.90

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