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PITX2 upregulation increases the risk of chronic atrial fibrillation in a dose-dependent manner by modulating I(Ks) and I(CaL)—insights from human atrial modelling
BACKGROUND: Functional analysis has shown that the paired-like homeodomain transcription factor 2 (PITX2) overexpression associated with atrial fibrillation (AF) leads to the slow delayed rectifier K(+) current (I(Ks)) increase and the L-type Ca(2+) current (I(CaL)) reduction observed in isolated ri...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
AME Publishing Company
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154416/ https://www.ncbi.nlm.nih.gov/pubmed/32309338 http://dx.doi.org/10.21037/atm.2020.01.90 |