Crystal structure of the catalytic D2 domain of the AAA+ ATPase p97 reveals a putative helical split‐washer‐type mechanism for substrate unfolding

Several pathologies have been associated with the AAA+ ATPase p97, an enzyme essential to protein homeostasis. Heterozygous polymorphisms in p97 have been shown to cause neurological disease, while elevated proteotoxic stress in tumours has made p97 an attractive cancer chemotherapy target. The cell...

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Detalles Bibliográficos
Autores principales: Stach, Lasse, Morgan, Rhodri Marc, Makhlouf, Linda, Douangamath, Alice, von Delft, Frank, Zhang, Xiaodong, Freemont, Paul S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Letters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154655/
https://www.ncbi.nlm.nih.gov/pubmed/31701538
http://dx.doi.org/10.1002/1873-3468.13667

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154655/
https://www.ncbi.nlm.nih.gov/pubmed/31701538
http://dx.doi.org/10.1002/1873-3468.13667

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