Oxalyl‐CoA Decarboxylase Enables Nucleophilic One‐Carbon Extension of Aldehydes to Chiral α‐Hydroxy Acids

The synthesis of complex molecules from simple, renewable carbon units is the goal of a sustainable economy. Here we explored the biocatalytic potential of the thiamine‐diphosphate‐dependent (ThDP) oxalyl‐CoA decarboxylase (OXC)/2‐hydroxyacyl‐CoA lyase (HACL) superfamily that naturally catalyzes the...

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Detalles Bibliográficos
Autores principales: Burgener, Simon, Cortina, Niña Socorro, Erb, Tobias J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154664/
https://www.ncbi.nlm.nih.gov/pubmed/31894608
http://dx.doi.org/10.1002/anie.201915155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154664/
https://www.ncbi.nlm.nih.gov/pubmed/31894608
http://dx.doi.org/10.1002/anie.201915155

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