Image‐Based Morphological Profiling Identifies a Lysosomotropic, Iron‐Sequestering Autophagy Inhibitor

Chemical proteomics is widely applied in small‐molecule target identification. However, in general it does not identify non‐protein small‐molecule targets, and thus, alternative methods for target identification are in high demand. We report the discovery of the autophagy inhibitor autoquin and the...

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Detalles Bibliográficos
Autores principales: Laraia, Luca, Garivet, Guillaume, Foley, Daniel J., Kaiser, Nadine, Müller, Sebastian, Zinken, Sarah, Pinkert, Thomas, Wilke, Julian, Corkery, Dale, Pahl, Axel, Sievers, Sonja, Janning, Petra, Arenz, Christoph, Wu, Yaowen, Rodriguez, Raphaël, Waldmann, Herbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154763/
https://www.ncbi.nlm.nih.gov/pubmed/31769920
http://dx.doi.org/10.1002/anie.201913712

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154763/
https://www.ncbi.nlm.nih.gov/pubmed/31769920
http://dx.doi.org/10.1002/anie.201913712

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