A Supramolecular Stabilizer of the 14‐3‐3ζ/ERα Protein‐Protein Interaction with a Synergistic Mode of Action

We report on a stabilizer of the interaction between 14‐3‐3ζ and the Estrogen Receptor alpha (ERα). ERα is a driver in the majority of breast cancers and 14‐3‐3 proteins are negative regulators of this nuclear receptor, making the stabilization of this protein‐protein interaction (PPI) an interestin...

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Detalles Bibliográficos
Autores principales: Gigante, Alba, Sijbesma, Eline, Sánchez‐Murcia, Pedro A., Hu, Xiaoyu, Bier, David, Bäcker, Sandra, Knauer, Shirley, Gago, Federico, Ottmann, Christian, Schmuck, Carsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155037/
https://www.ncbi.nlm.nih.gov/pubmed/31814236
http://dx.doi.org/10.1002/anie.201914517

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155037/
https://www.ncbi.nlm.nih.gov/pubmed/31814236
http://dx.doi.org/10.1002/anie.201914517

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