Metal Exchange in the Interprotein Zn(II)‐Binding Site of the Rad50 Hook Domain: Structural Insights into Cd(II)‐Induced DNA‐Repair Inhibition

Cd(II) is a major genotoxic agent that readily displaces Zn(II) in a multitude of zinc proteins, abrogates redox homeostasis, and deregulates cellular metalloproteome. To date, this displacement has been described mostly for cysteine(Cys)‐rich intraprotein binding sites in certain zinc finger domain...

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Detalles Bibliográficos
Autores principales: Padjasek, Michał, Maciejczyk, Maciej, Nowakowski, Michał, Kerber, Olga, Pyrka, Maciej, Koźmiński, Wiktor, Krężel, Artur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155053/
https://www.ncbi.nlm.nih.gov/pubmed/31846102
http://dx.doi.org/10.1002/chem.201904942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155053/
https://www.ncbi.nlm.nih.gov/pubmed/31846102
http://dx.doi.org/10.1002/chem.201904942

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