Functional Disruption of the Cancer‐Relevant Interaction between Survivin and Histone H3 with a Guanidiniocarbonyl Pyrrole Ligand

The protein Survivin is highly upregulated in most cancers and considered to be a key player in carcinogenesis. We explored a supramolecular approach to address Survivin as a drug target by inhibiting the protein–protein interaction of Survivin and its functionally relevant binding partner Histone H...

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Detalles Bibliográficos
Autores principales: Vallet, Cecilia, Aschmann, Dennis, Beuck, Christine, Killa, Matthias, Meiners, Annika, Mertel, Marcel, Ehlers, Martin, Bayer, Peter, Schmuck, Carsten, Giese, Michael, Knauer, Shirley K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155087/
https://www.ncbi.nlm.nih.gov/pubmed/31916356
http://dx.doi.org/10.1002/anie.201915400

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155087/
https://www.ncbi.nlm.nih.gov/pubmed/31916356
http://dx.doi.org/10.1002/anie.201915400

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