Analysis of an Active Deformylation Mechanism of 5‐Formyl‐deoxycytidine (fdC) in Stem Cells

The removal of 5‐methyl‐deoxycytidine (mdC) from promoter elements is associated with reactivation of the silenced corresponding genes. It takes place through an active demethylation process involving the oxidation of mdC to 5‐hydroxymethyl‐deoxycytidine (hmdC) and further on to 5‐formyl‐deoxycytidi...

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Detalles Bibliográficos
Autores principales: Schön, Alexander, Kaminska, Ewelina, Schelter, Florian, Ponkkonen, Eveliina, Korytiaková, Eva, Schiffers, Sarah, Carell, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155088/
https://www.ncbi.nlm.nih.gov/pubmed/31999041
http://dx.doi.org/10.1002/anie.202000414

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155088/
https://www.ncbi.nlm.nih.gov/pubmed/31999041
http://dx.doi.org/10.1002/anie.202000414

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