Chronic morphine regulates TRPM8 channels via MOR-PKCβ signaling

Postoperative shivering and cold hypersensitivity are major side effects of acute and chronic opioid treatments respectively. TRPM8 is a cold and menthol-sensitive channel found in a subset of dorsal root ganglion (DRG) nociceptors. Deletion or inhibition of the TRPM8 channel was found to prevent th...

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Detalles Bibliográficos
Autores principales: Iftinca, Mircea, Basso, Lilian, Flynn, Robyn, Kwok, Charlie, Roland, Corinne, Hassan, Ahmed, Defaye, Manon, Ramachandran, Rithwik, Trang, Tuan, Altier, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155267/
https://www.ncbi.nlm.nih.gov/pubmed/32290846
http://dx.doi.org/10.1186/s13041-020-00599-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155267/
https://www.ncbi.nlm.nih.gov/pubmed/32290846
http://dx.doi.org/10.1186/s13041-020-00599-0

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