GNAS, PDE4D, and PRKAR1A Mutations and GNAS Methylation Changes Are Not a Common Cause of Isolated Early-Onset Severe Obesity Among Finnish Children

Context: Pseudohypoparathyroidism type Ia (PHP1A) is caused by inactivating mutations involving GNAS exons 1–13, encoding the alpha-subunit of the stimulatory G protein (Gsα). Particularly PHP1A, but also other disorders involving the Gsα-cAMP-signaling pathway, have been associated with early-onset...

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Detalles Bibliográficos
Autores principales: Loid, Petra, Pekkinen, Minna, Reyes, Monica, Mustila, Taina, Viljakainen, Heli, Jüppner, Harald, Mäkitie, Outi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155765/
https://www.ncbi.nlm.nih.gov/pubmed/32318528
http://dx.doi.org/10.3389/fped.2020.00145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155765/
https://www.ncbi.nlm.nih.gov/pubmed/32318528
http://dx.doi.org/10.3389/fped.2020.00145

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