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Resveratrol Sensitizes Colorectal Cancer Cells to Cetuximab by Connexin 43 Upregulation-Induced Akt Inhibition

Cetuximab is a monoclonal antibody that acts as an anti-epidermal growth factor receptor (EGFR) agent. Cetuximab inhibits the phosphorylation and activation of EGFR and blocks downstream signal pathways of EGF/EGFR, including Ras-Raf-MAPK and PI3K-Akt pathways. Akt activation is an important factor...

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Detalles Bibliográficos
Autores principales:	Wang, Yijia, Wang, Wenhong, Wu, Xiaojing, Li, Chunjun, Huang, Yaping, Zhou, Huiyan, Cui, Yu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155766/ https://www.ncbi.nlm.nih.gov/pubmed/32318334 http://dx.doi.org/10.3389/fonc.2020.00383

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