Cryo-EM structures of S-OPA1 reveal its interactions with membrane and changes upon nucleotide binding

Mammalian mitochondrial inner membrane fusion is mediated by optic atrophy 1 (OPA1). Under physiological conditions, OPA1 undergoes proteolytic processing to form a membrane-anchored long isoform (L-OPA1) and a soluble short isoform (S-OPA1). A combination of L-OPA1 and S-OPA1 is essential for effic...

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Detalles Bibliográficos
Autores principales: Zhang, Danyang, Zhang, Yan, Ma, Jun, Zhu, Chunmei, Niu, Tongxin, Chen, Wenbo, Pang, Xiaoyun, Zhai, Yujia, Sun, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156267/
https://www.ncbi.nlm.nih.gov/pubmed/32228866
http://dx.doi.org/10.7554/eLife.50294

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156267/
https://www.ncbi.nlm.nih.gov/pubmed/32228866
http://dx.doi.org/10.7554/eLife.50294

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