Effect of UVC Irradiation on the Oxidation of Histidine in Monoclonal Antibodies

We oxidized histidine residues in monoclonal antibody drugs of immunoglobulin gamma 1 (IgG1) using ultraviolet C irradiation (UVC: 200–280 nm), which is known to be potent for sterilization or disinfection. Among the reaction products, we identified asparagine and aspartic acid by mass spectrometry....

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Detalles Bibliográficos
Autores principales: Miyahara, Yuya, Shintani, Koya, Hayashihara-Kakuhou, Kayoko, Zukawa, Takehiro, Morita, Yukihiro, Nakazawa, Takashi, Yoshida, Takuya, Ohkubo, Tadayasu, Uchiyama, Susumu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156388/
https://www.ncbi.nlm.nih.gov/pubmed/32286391
http://dx.doi.org/10.1038/s41598-020-63078-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156388/
https://www.ncbi.nlm.nih.gov/pubmed/32286391
http://dx.doi.org/10.1038/s41598-020-63078-5

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