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Effect of UVC Irradiation on the Oxidation of Histidine in Monoclonal Antibodies
We oxidized histidine residues in monoclonal antibody drugs of immunoglobulin gamma 1 (IgG1) using ultraviolet C irradiation (UVC: 200–280 nm), which is known to be potent for sterilization or disinfection. Among the reaction products, we identified asparagine and aspartic acid by mass spectrometry....
Autores principales: | Miyahara, Yuya, Shintani, Koya, Hayashihara-Kakuhou, Kayoko, Zukawa, Takehiro, Morita, Yukihiro, Nakazawa, Takashi, Yoshida, Takuya, Ohkubo, Tadayasu, Uchiyama, Susumu |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156388/ https://www.ncbi.nlm.nih.gov/pubmed/32286391 http://dx.doi.org/10.1038/s41598-020-63078-5 |
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