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The dynactin subunit DCTN1 controls osteoclastogenesis via the Cdc42/PAK2 pathway
Osteoclasts (OCs), cells specialized for bone resorption, are generated from monocyte/macrophage precursors by a differentiation process governed by RANKL. Here, we show that DCTN1, a key component of the dynactin complex, plays important roles in OC differentiation. The expression of DCTN1 was upre...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156411/ https://www.ncbi.nlm.nih.gov/pubmed/32210358 http://dx.doi.org/10.1038/s12276-020-0406-0 |