P2X7 receptor inhibition ameliorates dendritic spine pathology and social behavioral deficits in Rett syndrome mice

Dysregulated immunity has been implicated in the pathogenesis of neurodevelopmental disorders but its contribution to synaptic and behavioral deficits in Rett syndrome (RTT) remains unknown. P2X7 receptors (P2X7Rs) are unique purinergic receptors with pro-inflammatory functions. Here, we report in a...

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Detalles Bibliográficos
Autores principales: Garré, Juan Mauricio, Silva, Hernandez Moura, Lafaille, Juan J., Yang, Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156443/
https://www.ncbi.nlm.nih.gov/pubmed/32286307
http://dx.doi.org/10.1038/s41467-020-15590-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156443/
https://www.ncbi.nlm.nih.gov/pubmed/32286307
http://dx.doi.org/10.1038/s41467-020-15590-5

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