An in vivo platform to select and evolve aggregation-resistant proteins

Protein biopharmaceuticals are highly successful, but their utility is compromised by their propensity to aggregate during manufacture and storage. As aggregation can be triggered by non-native states, whose population is not necessarily related to thermodynamic stability, prediction of poorly-behav...

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Detalles Bibliográficos
Autores principales: Ebo, Jessica S., Saunders, Janet C., Devine, Paul W. A., Gordon, Alice M., Warwick, Amy S., Schiffrin, Bob, Chin, Stacey E., England, Elizabeth, Button, James D., Lloyd, Christopher, Bond, Nicholas J., Ashcroft, Alison E., Radford, Sheena E., Lowe, David C., Brockwell, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156504/
https://www.ncbi.nlm.nih.gov/pubmed/32286330
http://dx.doi.org/10.1038/s41467-020-15667-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156504/
https://www.ncbi.nlm.nih.gov/pubmed/32286330
http://dx.doi.org/10.1038/s41467-020-15667-1

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