Siponimod (BAF312) Activates Nrf2 While Hampering NFκB in Human Astrocytes, and Protects From Astrocyte-Induced Neurodegeneration

Multiple sclerosis (MS) is an inflammatory neurodegenerative disease of the central nervous system (CNS) with heterogeneous pathophysiology. In its progressive course oligodendrocyte and neuroaxonal damage is sustained by compartmentalized inflammation due to glial dysregulation. Siponimod (BAF312),...

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Detalles Bibliográficos
Autores principales: Colombo, Emanuela, Bassani, Claudia, De Angelis, Anthea, Ruffini, Francesca, Ottoboni, Linda, Comi, Giancarlo, Martino, Gianvito, Farina, Cinthia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156595/
https://www.ncbi.nlm.nih.gov/pubmed/32322257
http://dx.doi.org/10.3389/fimmu.2020.00635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156595/
https://www.ncbi.nlm.nih.gov/pubmed/32322257
http://dx.doi.org/10.3389/fimmu.2020.00635

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