Imaging small molecule-induced endosomal escape of siRNA

Small interfering RNAs (siRNAs) are a new class of promising therapeutic molecules that can be used for sequence-specific downregulation of disease-causing genes. However, endosomal entrapment of siRNA is a key hurdle for most delivery strategies, limiting the therapeutic effect. Here, we use live-c...

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Detalles Bibliográficos
Autores principales: Du Rietz, Hampus, Hedlund, Hampus, Wilhelmson, Sten, Nordenfelt, Pontus, Wittrup, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156650/
https://www.ncbi.nlm.nih.gov/pubmed/32286269
http://dx.doi.org/10.1038/s41467-020-15300-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156650/
https://www.ncbi.nlm.nih.gov/pubmed/32286269
http://dx.doi.org/10.1038/s41467-020-15300-1

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