Chronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodeling

The hexosamine biosynthetic pathway (HBP) plays critical roles in nutrient sensing, stress response, and cell growth. However, its contribution to cardiac hypertrophic growth and heart failure remains incompletely understood. Here, we show that the HBP is induced in cardiomyocytes during hypertrophi...

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Detalles Bibliográficos
Autores principales: Tran, Diem Hong, May, Herman I., Li, Qinfeng, Luo, Xiang, Huang, Jian, Zhang, Guangyu, Niewold, Erica, Wang, Xiaoding, Gillette, Thomas G., Deng, Yingfeng, Wang, Zhao V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156663/
https://www.ncbi.nlm.nih.gov/pubmed/32286306
http://dx.doi.org/10.1038/s41467-020-15640-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156663/
https://www.ncbi.nlm.nih.gov/pubmed/32286306
http://dx.doi.org/10.1038/s41467-020-15640-y

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