Transgene integration causes RARB downregulation in homozygous Tg4–42 mice

Alzheimer’s disease can be modelled by different transgenic mouse strains. To gain deeper insight into disease model mechanisms, the previously described Tg4–42 mouse was analysed for transgene integration. On RNA/DNA level the transgene integration resulted in more than 20 copy numbers and further...

Descripción completa

Detalles Bibliográficos
Autores principales: Hinteregger, Barbara, Loeffler, Tina, Flunkert, Stefanie, Neddens, Joerg, Birner-Gruenberger, Ruth, Bayer, Thomas A., Madl, Tobias, Hutter-Paier, Birgit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156671/
https://www.ncbi.nlm.nih.gov/pubmed/32286473
http://dx.doi.org/10.1038/s41598-020-63512-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156671/
https://www.ncbi.nlm.nih.gov/pubmed/32286473
http://dx.doi.org/10.1038/s41598-020-63512-8

Ejemplares similares