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Minimum epistasis interpolation for sequence-function relationships

Massively parallel phenotyping assays have provided unprecedented insight into how multiple mutations combine to determine biological function. While such assays can measure phenotypes for thousands to millions of genotypes in a single experiment, in practice these measurements are not exhaustive, s...

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Detalles Bibliográficos
Autores principales: Zhou, Juannan, McCandlish, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156698/
https://www.ncbi.nlm.nih.gov/pubmed/32286265
http://dx.doi.org/10.1038/s41467-020-15512-5