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Protease Inhibition Improves Healing of The Vaginal Wall after Obstetrical Injury: Results from a Preclinical Animal Model

Vaginal delivery with obstetrical trauma is a risk factor for pelvic organ prolapse later in life. Loss of fibulin-5 (FBLN5), an elastogenesis-promoting cellular matrix protein, results in prolapse in mice. Here, we evaluated effects of pregnancy, parturition, and obstetrical injury on FBLN5 content...

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Detalles Bibliográficos
Autores principales: Hamner, Jennifer, Florian-Rodriguez, Maria, Acevedo, Jesus, Shi, Haolin, Word, R. Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156712/
https://www.ncbi.nlm.nih.gov/pubmed/32286390
http://dx.doi.org/10.1038/s41598-020-63031-6