Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction

Small molecule inhibitor of the bromodomain and extraterminal domain (BET) family proteins is a promising option for cancer treatment. However, current BET inhibitors are limited by their potency or oral bioavailability. Here we report the discovery and characterization of NHWD-870, a BET inhibitor...

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Detalles Bibliográficos
Autores principales: Yin, Mingzhu, Guo, Ying, Hu, Rui, Cai, Wesley L., Li, Yao, Pei, Shiyao, Sun, Hongyin, Peng, Cong, Li, Jiali, Ye, Rui, Yang, Qiaohong, Wang, Nenghui, Tao, Yongguang, Chen, Xiang, Yan, Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156724/
https://www.ncbi.nlm.nih.gov/pubmed/32286255
http://dx.doi.org/10.1038/s41467-020-15290-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156724/
https://www.ncbi.nlm.nih.gov/pubmed/32286255
http://dx.doi.org/10.1038/s41467-020-15290-0

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