Natural killer cells modulate motor neuron-immune cell cross talk in models of Amyotrophic Lateral Sclerosis

In amyotrophic lateral sclerosis (ALS), immune cells and glia contribute to motor neuron (MN) degeneration. We report the presence of NK cells in post-mortem ALS motor cortex and spinal cord tissues, and the expression of NKG2D ligands on MNs. Using a mouse model of familial-ALS, hSOD1(G93A), we dem...

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Detalles Bibliográficos
Autores principales: Garofalo, Stefano, Cocozza, Germana, Porzia, Alessandra, Inghilleri, Maurizio, Raspa, Marcello, Scavizzi, Ferdinando, Aronica, Eleonora, Bernardini, Giovanni, Peng, Ling, Ransohoff, Richard M., Santoni, Angela, Limatola, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156729/
https://www.ncbi.nlm.nih.gov/pubmed/32286313
http://dx.doi.org/10.1038/s41467-020-15644-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156729/
https://www.ncbi.nlm.nih.gov/pubmed/32286313
http://dx.doi.org/10.1038/s41467-020-15644-8

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