Cargando…

Natural killer cells modulate motor neuron-immune cell cross talk in models of Amyotrophic Lateral Sclerosis

In amyotrophic lateral sclerosis (ALS), immune cells and glia contribute to motor neuron (MN) degeneration. We report the presence of NK cells in post-mortem ALS motor cortex and spinal cord tissues, and the expression of NKG2D ligands on MNs. Using a mouse model of familial-ALS, hSOD1(G93A), we dem...

Descripción completa

Detalles Bibliográficos
Autores principales:	Garofalo, Stefano, Cocozza, Germana, Porzia, Alessandra, Inghilleri, Maurizio, Raspa, Marcello, Scavizzi, Ferdinando, Aronica, Eleonora, Bernardini, Giovanni, Peng, Ling, Ransohoff, Richard M., Santoni, Angela, Limatola, Cristina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156729/ https://www.ncbi.nlm.nih.gov/pubmed/32286313 http://dx.doi.org/10.1038/s41467-020-15644-8

Ejemplares similares

The feeding behaviour of Amyotrophic Lateral Sclerosis mouse models is modulated by the Ca(2+)‐activated K(Ca)3.1 channels
por: Cocozza, Germana, et al.
Publicado: (2021)

Microglial crosstalk with astrocytes and immune cells in amyotrophic lateral sclerosis
por: Calafatti, Matteo, et al.
Publicado: (2023)

Natural killer cells and innate lymphoid cells 1 tune anxiety-like behavior and memory in mice via interferon-γ and acetylcholine
por: Garofalo, Stefano, et al.
Publicado: (2023)

Enriched Environment Cues Suggest a New Strategy to Counteract Glioma: Engineered rAAV2-IL-15 Microglia Modulate the Tumor Microenvironment
por: Mormino, Alessandro, et al.
Publicado: (2021)

Excessive rest time during active phase is reliably detected in a mouse model of myotonic dystrophy type 1 using home cage monitoring
por: Golini, Elisabetta, et al.
Publicado: (2023)

Partial Block by Riluzole of Muscle Sodium Channels in Myotubes from Amyotrophic Lateral Sclerosis Patients
por: Deflorio, Cristina, et al.
Publicado: (2014)

Microglial Potassium Channels: From Homeostasis to Neurodegeneration
por: Cocozza, Germana, et al.
Publicado: (2021)

Histone‐deacetylase 8 drives the immune response and the growth of glioma
por: Mormino, Alessandro, et al.
Publicado: (2021)

Microglia-Derived Small Extracellular Vesicles Reduce Glioma Growth by Modifying Tumor Cell Metabolism and Enhancing Glutamate Clearance through miR-124
por: Serpe, Carmela, et al.
Publicado: (2021)

Prevalence of amyotrophic lateral sclerosis in Latium region, Italy
por: Puopolo, Maria, et al.
Publicado: (2021)

A comprehensive approach for microbiota and health monitoring in mouse colonies using metagenomic shotgun sequencing
por: Scavizzi, Ferdinando, et al.
Publicado: (2021)

Microbiota and environmental health monitoring of mouse colonies by metagenomic shotgun sequencing
por: Lupini, Laura, et al.
Publicado: (2022)

Communication of diagnosis in amyotrophic lateral sclerosis: stratification of patients for the estimation of the individual needs
por: Pizzimenti, Alessia, et al.
Publicado: (2015)

Short-chain fatty acids promote the effect of environmental signals on the gut microbiome and metabolome in mice
por: Marrocco, Francesco, et al.
Publicado: (2022)

Data repurposing from digital home cage monitoring enlightens new perspectives on mouse motor behaviour and reduction principle
por: Fuochi, Sara, et al.
Publicado: (2023)

Functional Cross Talk between CXCR4 and PDGFR on Glioblastoma Cells Is Essential for Migration
por: Sciaccaluga, Miriam, et al.
Publicado: (2013)

Gut microbiota alterations affect glioma growth and innate immune cells involved in tumor immunosurveillance in mice
por: D'Alessandro, Giuseppina, et al.
Publicado: (2020)

Creatine Kinase and Progression Rate in Amyotrophic Lateral Sclerosis
por: Ceccanti, Marco, et al.
Publicado: (2020)

A Non-invasive Digital Biomarker for the Detection of Rest Disturbances in the SOD1G93A Mouse Model of ALS
por: Golini, Elisabetta, et al.
Publicado: (2020)

Connexin 30 deletion exacerbates cochlear senescence and age-related hearing loss
por: Paciello, Fabiola, et al.
Publicado: (2022)

Microglia modulate hippocampal synaptic transmission and sleep duration along the light/dark cycle
por: Corsi, Giorgio, et al.
Publicado: (2021)

Oral D-Aspartate Treatment Improves Sperm Fertility in Both Young and Adult B6N Mice
por: Raspa, Marcello, et al.
Publicado: (2022)

Enriched environment reduces glioma growth through immune and non-immune mechanisms in mice
por: Garofalo, Stefano, et al.
Publicado: (2015)

Nature killer cells in the central nervous system
por: Shi, Fu-Dong, et al.
Publicado: (2010)

Complement activation at the motor end-plates in amyotrophic lateral sclerosis
por: Bahia El Idrissi, Nawal, et al.
Publicado: (2016)

Attention and P300-based BCI performance in people with amyotrophic lateral sclerosis
por: Riccio, Angela, et al.
Publicado: (2013)

Splicing Players Are Differently Expressed in Sporadic Amyotrophic Lateral Sclerosis Molecular Clusters and Brain Regions
por: La Cognata, Valentina, et al.
Publicado: (2020)

Dysphagia in Amyotrophic Lateral Sclerosis: Impact on Patient Behavior, Diet Adaptation, and Riluzole Management
por: Onesti, Emanuela, et al.
Publicado: (2017)

Progression of Oropharyngeal Dysphagia in Amyotrophic Lateral Sclerosis: A Retrospective Cohort Study
por: Mariani, Laura, et al.
Publicado: (2021)

Laryngeal Sensitivity in Patients with Amyotrophic Lateral Sclerosis
por: Ruoppolo, Giovanni, et al.
Publicado: (2016)

Tofacitinib Suppresses Natural Killer Cells In Vitro and In Vivo: Implications for Amyotrophic Lateral Sclerosis
por: Figueroa-Romero, Claudia, et al.
Publicado: (2022)

Effects of Skin Stimulation on Sensory-Motor Networks Excitability: Possible Implications for Physical Training in Amyotrophic Lateral Sclerosis
por: Ceccanti, Marco, et al.
Publicado: (2022)

The activity of a PI3K δ-sparing inhibitor, MEN1611, in non-small cell lung cancer cells with constitutive activation of the PI3K/AKT/mTOR pathway
por: Papoff, Giuliana, et al.
Publicado: (2023)

On the Relationship Between Attention Processing and P300-Based Brain Computer Interface Control in Amyotrophic Lateral Sclerosis
por: Riccio, Angela, et al.
Publicado: (2018)

Calcium Signaling in the Photodamaged Skin: In Vivo Experiments and Mathematical Modeling
por: Donati, Viola, et al.
Publicado: (2021)

Modulating neurotoxicity through CX3CL1/CX3CR1 signaling
por: Limatola, Cristina, et al.
Publicado: (2014)

Cross-Talks between Natural Killer Cells and Distinct Subsets of Dendritic Cells
por: Ferlazzo, Guido, et al.
Publicado: (2014)

Natural killer cells-related immune traits and amyotrophic lateral sclerosis: A Mendelian randomization study
por: Gong, Zhenxiang, et al.
Publicado: (2022)

Multiple Levels of Chemokine Receptor Regulation in the Control of Mouse Natural Killer Cell Development
por: Bernardini, Giovanni, et al.
Publicado: (2014)

Early Social Enrichment Modulates Tumor Progression and p53 Expression in Adult Mice
por: Middei, Silvia, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_7fpfpjdnqt9ukeub3nq9hl4srq