Transcriptomic Profiling of Tumor-Infiltrating CD4(+)TIM-3(+) T Cells Reveals Their Suppressive, Exhausted, and Metastatic Characteristics in Colorectal Cancer Patients

T cell immunoglobulin mucin-3 (TIM-3) is an immune checkpoint identified as one of the key players in regulating T-cell responses. Studies have shown that TIM-3 is upregulated in the tumor microenvironment (TME). However, the precise role of TIM-3 in colorectal cancer (CRC) TME is yet to be elucidat...

Descripción completa

Detalles Bibliográficos
Autores principales: Sasidharan Nair, Varun, M Toor, Salman, Z Taha, Rowaida, Ahmed, Ayman A, Kurer, Mohamed A, Murshed, Khaled, Soofi, Madiha E, Ouararhni, Khalid, M. Alajez, Nehad, Abu Nada, Mohamed, Elkord, Eyad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157206/
https://www.ncbi.nlm.nih.gov/pubmed/32041340
http://dx.doi.org/10.3390/vaccines8010071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157206/
https://www.ncbi.nlm.nih.gov/pubmed/32041340
http://dx.doi.org/10.3390/vaccines8010071

Ejemplares similares