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Transcriptomic Profiling of Tumor-Infiltrating CD4(+)TIM-3(+) T Cells Reveals Their Suppressive, Exhausted, and Metastatic Characteristics in Colorectal Cancer Patients

T cell immunoglobulin mucin-3 (TIM-3) is an immune checkpoint identified as one of the key players in regulating T-cell responses. Studies have shown that TIM-3 is upregulated in the tumor microenvironment (TME). However, the precise role of TIM-3 in colorectal cancer (CRC) TME is yet to be elucidat...

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Detalles Bibliográficos
Autores principales:	Sasidharan Nair, Varun, M Toor, Salman, Z Taha, Rowaida, Ahmed, Ayman A, Kurer, Mohamed A, Murshed, Khaled, Soofi, Madiha E, Ouararhni, Khalid, M. Alajez, Nehad, Abu Nada, Mohamed, Elkord, Eyad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157206/ https://www.ncbi.nlm.nih.gov/pubmed/32041340 http://dx.doi.org/10.3390/vaccines8010071

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