Comparative Modeling of Drug Target Proteins

Mostrar otras versiones (1)

In this perspective, we begin by describing the comparative protein structure modeling technique and the accuracy of the corresponding models. We then discuss the significant role that comparative prediction plays in drug discovery. We focus on virtual ligand screening against comparative models and...

Descripción completa

Detalles Bibliográficos
Autores principales: Webb, B., Eswar, N., Fan, H., Khuri, N., Pieper, U., Dong, G.Q., Sali, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157477/
http://dx.doi.org/10.1016/B978-0-12-409547-2.11133-3
_version_ 1783522351147646976
author Webb, B.
Eswar, N.
Fan, H.
Khuri, N.
Pieper, U.
Dong, G.Q.
Sali, A.
author_facet Webb, B.
Eswar, N.
Fan, H.
Khuri, N.
Pieper, U.
Dong, G.Q.
Sali, A.
author_sort Webb, B.
collection PubMed
description In this perspective, we begin by describing the comparative protein structure modeling technique and the accuracy of the corresponding models. We then discuss the significant role that comparative prediction plays in drug discovery. We focus on virtual ligand screening against comparative models and illustrate the state-of-the-art by a number of specific examples.
format Online
Article
Text
id pubmed-7157477
institution National Center for Biotechnology Information
language English
publishDate 2014
record_format MEDLINE/PubMed
spelling pubmed-71574772020-04-15 Comparative Modeling of Drug Target Proteins Webb, B. Eswar, N. Fan, H. Khuri, N. Pieper, U. Dong, G.Q. Sali, A. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering Article In this perspective, we begin by describing the comparative protein structure modeling technique and the accuracy of the corresponding models. We then discuss the significant role that comparative prediction plays in drug discovery. We focus on virtual ligand screening against comparative models and illustrate the state-of-the-art by a number of specific examples. 2014 2014-10-01 /pmc/articles/PMC7157477/ http://dx.doi.org/10.1016/B978-0-12-409547-2.11133-3 Text en Copyright © 2014 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Webb, B.
Eswar, N.
Fan, H.
Khuri, N.
Pieper, U.
Dong, G.Q.
Sali, A.
Comparative Modeling of Drug Target Proteins
title Comparative Modeling of Drug Target Proteins
title_full Comparative Modeling of Drug Target Proteins
title_fullStr Comparative Modeling of Drug Target Proteins
title_full_unstemmed Comparative Modeling of Drug Target Proteins
title_short Comparative Modeling of Drug Target Proteins
title_sort comparative modeling of drug target proteins
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157477/
http://dx.doi.org/10.1016/B978-0-12-409547-2.11133-3
work_keys_str_mv AT webbb comparativemodelingofdrugtargetproteins
AT eswarn comparativemodelingofdrugtargetproteins
AT fanh comparativemodelingofdrugtargetproteins
AT khurin comparativemodelingofdrugtargetproteins
AT pieperu comparativemodelingofdrugtargetproteins
AT donggq comparativemodelingofdrugtargetproteins
AT salia comparativemodelingofdrugtargetproteins

Ejemplares similares