PrPSc with Seeding Activity Extensively Overlaps with Proteinase-Resistant PrPSc Rather than Infectious PrPSc

The disease-associated prion protein (PrPSc) has the ability to seed the conformational conversion of normal prion proteins into the amyloid fibril form. This prion seeding activity can be measured using an in vitro amplification assay termed real-time quaking-induced conversion (RT-QuIC). There is...

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Detalles Bibliográficos
Autores principales: Iwamaru, Yoshifumi, Matsuura, Yuichi, Miyazawa, Kohtaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157578/
https://www.ncbi.nlm.nih.gov/pubmed/32213939
http://dx.doi.org/10.3390/pathogens9030241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157578/
https://www.ncbi.nlm.nih.gov/pubmed/32213939
http://dx.doi.org/10.3390/pathogens9030241

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