Familial hypercholesterolemia class II low-density lipoprotein receptor response to statin treatment

Low-density lipoprotein (LDL) receptor (LDLR) mutations are the primary cause of familial hypercholesterolemia (FH). Class II LDLR mutations result in a misfolded LDLR retained in the endoplasmic reticulum (ER). We have developed a model of FH class II and CRISPR-corrected induced pluripotent stem c...

Descripción completa

Detalles Bibliográficos
Autores principales: Omer, Linda, Hindi, Lubna, Militello, Giuseppe, Stivers, Katlin B., Tien, Kenneth C., Boyd, Nolan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157586/
https://www.ncbi.nlm.nih.gov/pubmed/32005714
http://dx.doi.org/10.1242/dmm.042911

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157586/
https://www.ncbi.nlm.nih.gov/pubmed/32005714
http://dx.doi.org/10.1242/dmm.042911

Ejemplares similares