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Familial hypercholesterolemia class II low-density lipoprotein receptor response to statin treatment

Low-density lipoprotein (LDL) receptor (LDLR) mutations are the primary cause of familial hypercholesterolemia (FH). Class II LDLR mutations result in a misfolded LDLR retained in the endoplasmic reticulum (ER). We have developed a model of FH class II and CRISPR-corrected induced pluripotent stem c...

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Detalles Bibliográficos
Autores principales:	Omer, Linda, Hindi, Lubna, Militello, Giuseppe, Stivers, Katlin B., Tien, Kenneth C., Boyd, Nolan L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157586/ https://www.ncbi.nlm.nih.gov/pubmed/32005714 http://dx.doi.org/10.1242/dmm.042911

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