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Specific Substitutions in Region V2 of gp120 env confer SHIV Neutralisation Resistance

A tier 2 SHIV-MK38 strain was obtained after two in vivo passages of tier 1 SHIV-MK1. SHIV-MK38#818, cloned from the MK38 strain, was neutralisation-resistant, like the parental MK38 strain, to SHIV-infected monkey plasma (MP), HIV-1-infected human pooled plasma (HPP), and KD247 monoclonal antibody...

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Detalles Bibliográficos
Autores principales: Pisil, Yalcin, Yazici, Zafer, Shida, Hisatoshi, Matsushita, Shuzo, Miura, Tomoyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157653/
https://www.ncbi.nlm.nih.gov/pubmed/32138199
http://dx.doi.org/10.3390/pathogens9030181