Protection and Safety Evaluation of Live Constructions Derived from the Pgm(−) and pPCP1(−) Yersinia pestis Strain

Based on a live attenuated Yersinia pestis KIM10(pCD1Ap) strain (Pgm(−), pPCP1(−)), we attempted to engineer its lipid A species to achieve improvement of immunogenicity and safety. A mutant strain designated as YPS19(pCD1Ap), mainly synthesizing the hexa-acylated lipid A, and another mutant strain...

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Detalles Bibliográficos
Autores principales: Wang, Xiuran, Singh, Amit K., Sun, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157699/
https://www.ncbi.nlm.nih.gov/pubmed/32098032
http://dx.doi.org/10.3390/vaccines8010095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157699/
https://www.ncbi.nlm.nih.gov/pubmed/32098032
http://dx.doi.org/10.3390/vaccines8010095

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