Statin Drugs Plus Th1 Cytokines Potentiate Apoptosis and Ras Delocalization in Human Breast Cancer Lines and Combine with Dendritic Cell-Based Immunotherapy to Suppress Tumor Growth in a Mouse Model of HER-2(pos) Disease

A dendritic cell-based, Type 1 Helper T cell (Th1)-polarizing anti-Human Epidermal Growth Factor Receptor-2 (HER-2) vaccine supplied in the neoadjuvant setting eliminates disease in up to 30% of recipients with HER-2-positive (HER-2(pos)) ductal carcinoma in situ (DCIS). We hypothesized that drugs w...

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Detalles Bibliográficos
Autores principales: Oechsle, Crystal M., Showalter, Loral E., Novak, Colleen M., Czerniecki, Brain J., Koski, Gary K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157728/
https://www.ncbi.nlm.nih.gov/pubmed/32041347
http://dx.doi.org/10.3390/vaccines8010072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157728/
https://www.ncbi.nlm.nih.gov/pubmed/32041347
http://dx.doi.org/10.3390/vaccines8010072

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