Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors

Hepatitis C virus (HCV) infects millions of people worldwide, causing chronic liver disease that can lead to cirrhosis, hepatocellular carcinoma, and liver transplant. In the last several years, the advent of direct-acting antivirals, including NS3/4A protease inhibitors (PIs), has remarkably improv...

Descripción completa

Detalles Bibliográficos
Autores principales: Matthew, Ashley N., Zephyr, Jacqueto, Nageswara Rao, Desaboini, Henes, Mina, Kamran, Wasih, Kosovrasti, Klajdi, Hedger, Adam K., Lockbaum, Gordon J., Timm, Jennifer, Ali, Akbar, Kurt Yilmaz, Nese, Schiffer, Celia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157764/
https://www.ncbi.nlm.nih.gov/pubmed/32234812
http://dx.doi.org/10.1128/mBio.00172-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157764/
https://www.ncbi.nlm.nih.gov/pubmed/32234812
http://dx.doi.org/10.1128/mBio.00172-20

Ejemplares similares