Cargando…
Deletion of the Zinc Transporter Lipoprotein AdcAII Causes Hyperencapsulation of Streptococcus pneumoniae Associated with Distinct Alleles of the Type I Restriction-Modification System
The capsule is the dominant Streptococcus pneumoniae virulence factor, yet how variation in capsule thickness is regulated is poorly understood. Here, we describe an unexpected relationship between mutation of adcAII, which encodes a zinc uptake lipoprotein, and capsule thickness. Partial deletion o...
Autores principales: | Durmort, Claire, Ercoli, Giuseppe, Ramos-Sevillano, Elisa, Chimalapati, Suneeta, Haigh, Richard D., De Ste Croix, Megan, Gould, Katherine, Hinds, Jason, Guerardel, Yann, Vernet, Thierry, Oggioni, Marco, Brown, Jeremy S. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157770/ https://www.ncbi.nlm.nih.gov/pubmed/32234814 http://dx.doi.org/10.1128/mBio.00445-20 |
Ejemplares similares
-
AdcAII of Streptococcus pneumoniae Affects Pneumococcal Invasiveness
por: Brown, Lindsey R., et al.
Publicado: (2016) -
New Insights into Histidine Triad Proteins: Solution Structure of a Streptococcus pneumoniae PhtD Domain and Zinc Transfer to AdcAII
por: Bersch, Beate, et al.
Publicado: (2013) -
The AdcACB/AdcAII system is essential for zinc homeostasis and an important contributor of Enterococcus faecalis virulence
por: Lam, Ling Ning, et al.
Publicado: (2022) -
Conformation of the Solute-Binding Protein AdcAII Influences Zinc Uptake in Streptococcus pneumoniae
por: Župan, Marina L., et al.
Publicado: (2021) -
Effects of Deletion of the Streptococcus pneumoniae Lipoprotein Diacylglyceryl Transferase Gene lgt on ABC Transporter Function and on Growth In Vivo
por: Chimalapati, Suneeta, et al.
Publicado: (2012)