Histidine-Triad Hydrolases Provide Resistance to Peptide-Nucleotide Antibiotics

The Escherichia coli microcin C (McC) and related compounds are potent Trojan horse peptide-nucleotide antibiotics. The peptide part facilitates transport into sensitive cells. Inside the cell, the peptide part is degraded by nonspecific peptidases releasing an aspartamide-adenylate containing a pho...

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Detalles Bibliográficos
Autores principales: Yagmurov, Eldar, Tsibulskaya, Darya, Livenskyi, Alexey, Serebryakova, Marina, Wolf, Yury I., Borukhov, Sergei, Severinov, Konstantin, Dubiley, Svetlana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157772/
https://www.ncbi.nlm.nih.gov/pubmed/32265328
http://dx.doi.org/10.1128/mBio.00497-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157772/
https://www.ncbi.nlm.nih.gov/pubmed/32265328
http://dx.doi.org/10.1128/mBio.00497-20

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