MiRNA Targeted NP Genome of Live Attenuated Influenza Vaccines Provide Cross-Protection against a Lethal Influenza Virus Infection

The miRNA-based strategy has been used to develop live attenuated influenza vaccines. In this study, the nucleoprotein (NP) genome segment of the influenza virus was inserted by different perfect miRNA-192-5p target sites, and the virus was rescued by standard reverse genetics method, so as to verif...

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Detalles Bibliográficos
Autores principales: Gao, Feixia, Yang, Tianhan, Liu, Xueying, Xiong, Feifei, Luo, Jian, Yi, Yinglei, Fan, Jiangfeng, Chen, Ze, Tan, Wen-Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158662/
https://www.ncbi.nlm.nih.gov/pubmed/32028575
http://dx.doi.org/10.3390/vaccines8010065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158662/
https://www.ncbi.nlm.nih.gov/pubmed/32028575
http://dx.doi.org/10.3390/vaccines8010065

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