Neutralizing Antibody Induction by HIV-1 Envelope Glycoprotein SOSIP Trimers on Iron Oxide Nanoparticles May Be Impaired by Mannose Binding Lectin

We covalently attached human immunodeficiency virus type 1 (HIV-1) Env SOSIP trimers to iron oxide nanoparticles (IO-NPs) to create a particulate immunogen for neutralizing antibody (NAb) induction. The attached trimers, ∼20 per particle, retained native-like antigenicity, judged by reactivity with...

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Detalles Bibliográficos
Autores principales: Ringe, Rajesh P., Cruz Portillo, Victor M., Dosenovic, Pia, Ketas, Thomas J., Ozorowski, Gabriel, Nogal, Bartek, Perez, Lautaro, LaBranche, Celia C., Lim, Jillian, Francomano, Erik, Wilson, Ian A., Sanders, Rogier W., Ward, Andrew B., Montefiori, David C., Nussenzweig, Michel C., Klasse, P. J., Cupo, Albert, Moore, John P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158715/
https://www.ncbi.nlm.nih.gov/pubmed/31852794
http://dx.doi.org/10.1128/JVI.01883-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158715/
https://www.ncbi.nlm.nih.gov/pubmed/31852794
http://dx.doi.org/10.1128/JVI.01883-19

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