Cargando…

Neurokinin 3 Receptor Antagonists Do Not Increase FSH or Estradiol Secretion in Menopausal Women

BACKGROUND: Neurokinin 3 receptor (NK3R) antagonism is a promising novel treatment for menopausal flashes. However, to avoid adverse hormonal effects it is clinically important to first confirm whether gonadotropin and estradiol concentrations change as a result of their administration. METHODS: Sin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Prague, Julia K, Abbara, Ali, Comninos, Alexander N, Jayasena, Channa N, Higham, Claire E, Adaway, Jo, Keevil, Brian G, Veldhuis, Johannes D, Dhillo, Waljit S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Clinical Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159071/ https://www.ncbi.nlm.nih.gov/pubmed/32318647 http://dx.doi.org/10.1210/jendso/bvz009

Ejemplares similares

Investigating the KNDy Hypothesis in Humans by Coadministration of Kisspeptin, Neurokinin B, and Naltrexone in Men
por: Narayanaswamy, Shakunthala, et al.
Publicado: (2016)

Effects of Neurokinin B Administration on Reproductive Hormone Secretion in Healthy Men and Women
por: Jayasena, Channa N., et al.
Publicado: (2014)

Treating hot flushes with a neurokinin 3 receptor antagonist
por: Prague, Julia K., et al.
Publicado: (2017)

OR11-4 Determining the Relationship between Hot Flushes and LH Pulses in Menopausal Women Using Mathematical Modelling
por: Dhillo, Waljit, et al.
Publicado: (2019)

Neurokinin 3 receptor antagonism as a novel treatment for menopausal hot flushes: a phase 2, randomised, double-blind, placebo-controlled trial
por: Prague, Julia K, et al.
Publicado: (2017)

Determining the Relationship Between Hot Flushes and LH Pulses in Menopausal Women Using Mathematical Modeling
por: Prague, Julia K, et al.
Publicado: (2019)

Neurokinin 3 receptor antagonism rapidly improves vasomotor symptoms with sustained duration of action
por: Prague, Julia K., et al.
Publicado: (2018)

Neurokinin B Administration Induces Hot Flushes in Women
por: Jayasena, Channa N., et al.
Publicado: (2015)

Subcutaneous infusion of kisspeptin‐54 stimulates gonadotrophin release in women and the response correlates with basal oestradiol levels
por: Narayanaswamy, Shakunthala, et al.
Publicado: (2015)

Ovarian Hyperstimulation Syndrome (OHSS) requiring Intensive Care Unit (ICU) admission between 1996-2020 in England, Wales, and Northern Ireland
por: Abbara, Ali, et al.
Publicado: (2022)

Elinzanetant (NT-814), a Neurokinin 1,3 Receptor Antagonist, Reduces Estradiol and Progesterone in Healthy Women
por: Pawsey, Steve, et al.
Publicado: (2021)

Neurokinin Receptor Antagonist, Fezolinetant, for Treatment of Menopausal Vasomotor Symptoms
por: Pinkerton, JoAnn V, et al.
Publicado: (2023)

SUN-LB58 Repeated Once-Daily Administration of the Non-Hormonal Neurokinin 1,3 Receptor Antagonist NT-814 Reduces LH, Estradiol and Progesterone in Healthy Women
por: Dhillo, Waljit Singh, et al.
Publicado: (2020)

Comprehensive Review on Kisspeptin and Its Role in Reproductive Disorders
por: Clarke, Holly, et al.
Publicado: (2015)

FSH Requirements for Follicle Growth During Controlled Ovarian Stimulation
por: Abbara, Ali, et al.
Publicado: (2019)

Effects of distinct Polycystic Ovary Syndrome phenotypes on bone health
por: Mills, Edouard G., et al.
Publicado: (2023)

Increasing LH Pulsatility in Women With Hypothalamic Amenorrhoea Using Intravenous Infusion of Kisspeptin-54
por: Jayasena, Channa N., et al.
Publicado: (2014)

Kisspeptin in the Prediction of Pregnancy Complications
por: Tsoutsouki, Jovanna, et al.
Publicado: (2022)

Use of kisspeptin to trigger oocyte maturation during in vitro fertilisation (IVF) treatment
por: Sharma, Bhavna, et al.
Publicado: (2022)

Invited review: Translating kisspeptin and neurokinin B biology into new therapies for reproductive health
por: Mills, Edouard G., et al.
Publicado: (2022)

Neurokinin 3 receptor antagonists for menopausal vasomotor symptoms, an appraisal
por: Gompel, Anne, et al.
Publicado: (2023)

Current Perspectives on Kisspeptins Role in Behaviour
por: Mills, Edouard G., et al.
Publicado: (2022)

Kisspeptin and Testicular Function—Is It Necessary?
por: Sharma, Aditi, et al.
Publicado: (2020)

Kisspeptin signaling in the amygdala modulates reproductive hormone secretion
por: Comninos, Alexander N., et al.
Publicado: (2015)

OR06-2 Kisspeptin Enhances Brain Processing of Olfactory and Visual Cues of Attraction in Men
por: Yang, Lisa, et al.
Publicado: (2019)

OR32-3 Kisspeptin- a Novel Clinical Test of Hypothalamic Function in Men with Hypogonadotrophic Hypogonadism
por: Phylactou, Maria, et al.
Publicado: (2019)

Neurokinin receptor antagonists as potential non-hormonal treatments for vasomotor symptoms of menopause
por: Conklin, Melissa, et al.
Publicado: (2023)

Survey of endocrinologists managing recovery from anabolic androgenic steroid induced hypogonadism
por: Grant, Bonnie, et al.
Publicado: (2023)

Efficacy of Kisspeptin-54 to Trigger Oocyte Maturation in Women at High Risk of Ovarian Hyperstimulation Syndrome (OHSS) During In Vitro Fertilization (IVF) Therapy
por: Abbara, Ali, et al.
Publicado: (2015)

Frequent falls and confusion: recurrent hypoglycemia in a patient with tuberous sclerosis complex
por: Comninos, Alexander N., et al.
Publicado: (2018)

Intrinsic links among sex, emotion, and reproduction
por: Yang, Lisa, et al.
Publicado: (2018)

Targeting Elevated GnRH Pulsatility to Treat Polycystic Ovary Syndrome
por: Abbara, Ali, et al.
Publicado: (2021)

Direct comparison of the effects of intravenous kisspeptin-10, kisspeptin-54 and GnRH on gonadotrophin secretion in healthy men
por: Jayasena, C.N., et al.
Publicado: (2015)

LBMON233 Hormonebayes: A Novel Bayesian Toolbox For Analysis Of Pulsatile Hormone Dynamics
por: Voliotis, Margaritis, et al.
Publicado: (2022)

Correction: Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo
por: d’Anglemont de Tassigny, Xavier, et al.
Publicado: (2018)

Animal Models of Diabetes-Related Male Hypogonadism
por: Dimakopoulou, Anastasia, et al.
Publicado: (2019)

Insulin-like peptide 3 (INSL3) in congenital hypogonadotrophic hypogonadism (CHH) in boys with delayed puberty and adult men
por: Abbara, Ali, et al.
Publicado: (2022)

Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo
por: d'Anglemont de Tassigny, Xavier, et al.
Publicado: (2017)

Assessing hypothalamic pituitary gonadal function in reproductive disorders
por: Koysombat, Kanyada, et al.
Publicado: (2023)

Modulations of human resting brain connectivity by kisspeptin enhance sexual and emotional functions
por: Comninos, Alexander N., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_dq13kvgqjhobbsm1ddo1pbn7gv