Polyunsaturated fatty acid analogues differentially affect cardiac Na(V), Ca(V), and K(V) channels through unique mechanisms

The cardiac ventricular action potential depends on several voltage-gated ion channels, including Na(V), Ca(V), and K(V) channels. Mutations in these channels can cause Long QT Syndrome (LQTS) which increases the risk for ventricular fibrillation and sudden cardiac death. Polyunsaturated fatty acids...

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Detalles Bibliográficos
Autores principales: Bohannon, Briana M, de la Cruz, Alicia, Wu, Xiaoan, Jowais, Jessica J, Perez, Marta E, Dykxhoorn, Derek M, Liin, Sara I, Larsson, H Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159882/
https://www.ncbi.nlm.nih.gov/pubmed/32207683
http://dx.doi.org/10.7554/eLife.51453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159882/
https://www.ncbi.nlm.nih.gov/pubmed/32207683
http://dx.doi.org/10.7554/eLife.51453

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