Cargando…

Polyunsaturated fatty acid analogues differentially affect cardiac Na(V), Ca(V), and K(V) channels through unique mechanisms

The cardiac ventricular action potential depends on several voltage-gated ion channels, including Na(V), Ca(V), and K(V) channels. Mutations in these channels can cause Long QT Syndrome (LQTS) which increases the risk for ventricular fibrillation and sudden cardiac death. Polyunsaturated fatty acids...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bohannon, Briana M, de la Cruz, Alicia, Wu, Xiaoan, Jowais, Jessica J, Perez, Marta E, Dykxhoorn, Derek M, Liin, Sara I, Larsson, H Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Structural Biology and Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159882/ https://www.ncbi.nlm.nih.gov/pubmed/32207683 http://dx.doi.org/10.7554/eLife.51453

Ejemplares similares

Correction: Polyunsaturated fatty acid analogues differentially affect cardiac Na(V), Ca(V), and K(V) channels through unique mechanisms
por: Bohannon, Briana M, et al.
Publicado: (2020)

Mechanistic insights into robust cardiac I(Ks) potassium channel activation by aromatic polyunsaturated fatty acid analogues
por: Bohannon, Briana M, et al.
Publicado: (2023)

KCNE1 tunes the sensitivity of K(V)7.1 to polyunsaturated fatty acids by moving turret residues close to the binding site
por: Larsson, Johan E, et al.
Publicado: (2018)

Mechanistic insights into robust cardiac I(Ks) potassium channel activation by aromatic polyunsaturated fatty acid analogues
por: Bohannon, Briana M., et al.
Publicado: (2023)

Allosteric regulators selectively prevent Ca(2+)-feedback of Ca(V) and Na(V) channels
por: Niu, Jacqueline, et al.
Publicado: (2018)

Fatty acid analogue N-arachidonoyl taurine restores function of I(Ks) channels with diverse long QT mutations
por: Liin, Sara I, et al.
Publicado: (2016)

Polyunsaturated fatty acids produce a range of activators for heterogeneous I(Ks) channel dysfunction
por: Bohannon, Briana M., et al.
Publicado: (2019)

Conserved biophysical features of the Ca(V)2 presynaptic Ca(2+) channel homologue from the early-diverging animal Trichoplax adhaerens
por: Gauberg, Julia, et al.
Publicado: (2021)

Computational design of peptides to target Na(V)1.7 channel with high potency and selectivity for the treatment of pain
por: Nguyen, Phuong T, et al.
Publicado: (2022)

Binary architecture of the Na(v)1.2-β2 signaling complex
por: Das, Samir, et al.
Publicado: (2016)

Ca(2+) entry into neurons is facilitated by cooperative gating of clustered Ca(V)1.3 channels
por: Moreno, Claudia M, et al.
Publicado: (2016)

Graded Ca(2+)/calmodulin-dependent coupling of voltage-gated Ca(V)1.2 channels
por: Dixon, Rose E, et al.
Publicado: (2015)

Cryo-EM reveals an unprecedented binding site for Na(V)1.7 inhibitors enabling rational design of potent hybrid inhibitors
por: Kschonsak, Marc, et al.
Publicado: (2023)

Timothy Mutation Disrupts the Link between Activation and Inactivation in Ca(V)1.2 Protein
por: Depil, Katrin, et al.
Publicado: (2011)

Mechanical inhibition of isolated V(o) from V/A-ATPase for proton conductance
por: Kishikawa, Jun-ichi, et al.
Publicado: (2020)

Polyunsaturated Fatty Acids as Modulators of K(V)7 Channels
por: Larsson, Johan E., et al.
Publicado: (2020)

Structure of a TRPM2 channel in complex with Ca(2+) explains unique gating regulation
por: Zhang, Zhe, et al.
Publicado: (2018)

Dichotomous role of the human mitochondrial Na(+)/Ca2(+)/Li(+) exchanger NCLX in colorectal cancer growth and metastasis
por: Pathak, Trayambak, et al.
Publicado: (2020)

Correction: Dichotomous role of the human mitochondrial Na(+)/Ca2(+)/Li(+) exchanger NCLX in colorectal cancer growth and metastasis
por: Pathak, Trayambak, et al.
Publicado: (2023)

Molecular mimicking of C-terminal phosphorylation tunes the surface dynamics of Ca(V)1.2 calcium channels in hippocampal neurons
por: Folci, Alessandra, et al.
Publicado: (2018)

Structure of SARS-CoV-2 M protein in lipid nanodiscs
por: Dolan, Kimberly A, et al.
Publicado: (2022)

ω‐6 and ω‐9 polyunsaturated fatty acids with double bonds near the carboxyl head have the highest affinity and largest effects on the cardiac I(K) (s) potassium channel
por: Bohannon, Briana M., et al.
Publicado: (2018)

Proximal clustering between BK and Ca(V)1.3 channels promotes functional coupling and BK channel activation at low voltage
por: Vivas, Oscar, et al.
Publicado: (2017)

Discovery and characterization of H(v)1-type proton channels in reef-building corals
por: Rangel-Yescas, Gisela, et al.
Publicado: (2021)

Asymmetric recognition of HIV-1 Envelope trimer by V1V2 loop-targeting antibodies
por: Wang, Haoqing, et al.
Publicado: (2017)

Sterically confined rearrangements of SARS-CoV-2 Spike protein control cell invasion
por: Dodero-Rojas, Esteban, et al.
Publicado: (2021)

Structures of topoisomerase V in complex with DNA reveal unusual DNA-binding mode and novel relaxation mechanism
por: Osterman, Amy, et al.
Publicado: (2022)

High-resolution structures of the actomyosin-V complex in three nucleotide states provide insights into the force generation mechanism
por: Pospich, Sabrina, et al.
Publicado: (2021)

Revealing druggable cryptic pockets in the Nsp1 of SARS-CoV-2 and other β-coronaviruses by simulations and crystallography
por: Borsatto, Alberto, et al.
Publicado: (2022)

The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins
por: Miller, Alexandria N, et al.
Publicado: (2023)

N501Y mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor ACE2
por: Tian, Fang, et al.
Publicado: (2021)

A novel region in the Ca(V)2.1 α(1) subunit C-terminus regulates fast synaptic vesicle fusion and vesicle docking at the mammalian presynaptic active zone
por: Lübbert, Matthias, et al.
Publicado: (2017)

A Na(+) leak channel cloned from Trichoplax adhaerens extends extracellular pH and Ca(2+) sensing for the DEG/ENaC family close to the base of Metazoa
por: Elkhatib, Wassim, et al.
Publicado: (2019)

ER-luminal [Ca(2+)] regulation of InsP(3) receptor gating mediated by an ER-luminal peripheral Ca(2+)-binding protein
por: Vais, Horia, et al.
Publicado: (2020)

Pore mutation N617D in the skeletal muscle DHPR blocks Ca(2+) influx due to atypical high-affinity Ca(2+) binding
por: Dayal, Anamika, et al.
Publicado: (2021)

The mechanism of MICU-dependent gating of the mitochondrial Ca(2+)uniporter
por: Garg, Vivek, et al.
Publicado: (2021)

The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism
por: Stanisich, Jessica J, et al.
Publicado: (2020)

Distinctive mechanisms of epilepsy-causing mutants discovered by measuring S4 movement in KCNQ2 channels
por: Edmond, Michaela A, et al.
Publicado: (2022)

Single-molecule analysis reveals rotational substeps and chemo-mechanical coupling scheme of Enterococcus hirae V(1)-ATPase
por: Iida, Tatsuya, et al.
Publicado: (2019)

Structural basis for allosteric control of the SERCA-Phospholamban membrane complex by Ca(2+) and phosphorylation
por: Weber, Daniel K, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_r8vbkn9i7eav91m8iotouotkq0