O-GlcNAc transferase promotes influenza A virus–induced cytokine storm by targeting interferon regulatory factor–5

In this study, we demonstrated an essential function of the hexosamine biosynthesis pathway (HBP)–associated O-linked β-N-acetylglucosamine (O-GlcNAc) signaling in influenza A virus (IAV)–induced cytokine storm. O-GlcNAc transferase (OGT), a key enzyme for protein O-GlcNAcylation, mediated IAV-induc...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Qiming, Fang, Peining, He, Rui, Li, Mengqi, Yu, Haisheng, Zhou, Li, Yi, Yu, Wang, Fubing, Rong, Yuan, Zhang, Yi, Chen, Aidong, Peng, Nanfang, Lin, Yong, Lu, Mengji, Zhu, Ying, Peng, Guoping, Rao, Liqun, Liu, Shi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159909/
https://www.ncbi.nlm.nih.gov/pubmed/32494619
http://dx.doi.org/10.1126/sciadv.aaz7086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159909/
https://www.ncbi.nlm.nih.gov/pubmed/32494619
http://dx.doi.org/10.1126/sciadv.aaz7086

Ejemplares similares