Bypassing mitochondrial complex III using alternative oxidase inhibits acute pulmonary oxygen sensing

Mitochondria play an important role in sensing both acute and chronic hypoxia in the pulmonary vasculature, but their primary oxygen-sensing mechanism and contribution to stabilization of the hypoxia-inducible factor (HIF) remains elusive. Alteration of the mitochondrial electron flux and increased...

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Detalles Bibliográficos
Autores principales: Sommer, Natascha, Alebrahimdehkordi, Nasim, Pak, Oleg, Knoepp, Fenja, Strielkov, Ievgen, Scheibe, Susan, Dufour, Eric, Andjelković, Ana, Sydykov, Akylbek, Saraji, Alireza, Petrovic, Aleksandar, Quanz, Karin, Hecker, Matthias, Kumar, Manish, Wahl, Joel, Kraut, Simone, Seeger, Werner, Schermuly, Ralph T., Ghofrani, Hossein A., Ramser, Kerstin, Braun, Thomas, Jacobs, Howard T., Weissmann, Norbert, Szibor, Marten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159913/
https://www.ncbi.nlm.nih.gov/pubmed/32426457
http://dx.doi.org/10.1126/sciadv.aba0694

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159913/
https://www.ncbi.nlm.nih.gov/pubmed/32426457
http://dx.doi.org/10.1126/sciadv.aba0694

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